BPC 157 (3mg)

Description

BPC 157 (Body Protection Compound-157) is a 15 amino acid pentadecapeptide. The amino acid sequence in BPC 157 is similar to a portion of the human BPC amino acid sequence. Human BPC is found in gastric juice. Experiments have shown that BPC 157 improves wound healing, including tendon wounds such as cut Achilles tendons in rats. The aim of this study was to investigate the likely mechanism that BPC 157 uses to accelerate the healing process of an injured tendon. Two groups of tendon explants were used in the study, of which one group was cultured in a medium containing BPC 157 and the other group was cultured in a medium lacking BPC 157. These cultures were then examined for tendon fibroblast growth. Such growths indicate tendon regeneration. The results showed that explant growth was significantly accelerated in a culture containing BPC 157 compared to a culture lacking BPC 157. In addition, the MTT assay did show that BPC 157 did not directly affect cell proliferation in a culture of Achilles derived from rats. tendon. However, the results also showed that BPC 157 significantly increased cell survival under oxidative stress. In addition, the Transwell filter migration assay showed that BPC 157 significantly increased fibroblast migration in vitro in a dose-dependent manner. Moreover, BPC 157 accelerated the dispersion of fibroblasts in culture dishes in a dose dependent manner. The MTT assay indeed showed that BPC 157 had no direct effect on cell proliferation in rat Achilles tendon culture.However, the results also showed that BPC 157 significantly increased cell survival under oxidative stress. In addition, the Transwell filter migration assay showed that BPC 157 significantly increased fibroblast migration in vitro in a dose-dependent manner. Moreover, BPC 157 accelerated the dispersion of fibroblasts in culture dishes in a dose dependent manner. The MTT assay indeed showed that BPC 157 had no direct effect on cell proliferation in rat Achilles tendon culture. However, the results also showed that BPC 157 significantly increased cell survival under oxidative stress. In addition, the Transwell filter migration assay showed that BPC 157 significantly increased fibroblast migration in vitro in a dose-dependent manner. Moreover, BPC 157 accelerated the dispersion of fibroblasts in culture dishes in a dose dependent manner.